mini-kidney Archives - Institute for Bioengineering of Catalonia

October 31, 2025

First transplant in pigs of modified porcine kidneys with human renal organoids

A research team has developed pioneering technology that enables human kidney organoids to be produced on a scalable basis. These organoids can then be combined with pig kidneys outside the body and transplanted back into the same animal in a viable manner. The experiment, led by the Institute for Bioengineering of Catalonia (IBEC), is in the preclinical phase. It confirms the safety and viability of the procedure, paving the way for future trials involving humans. In the long term, this approach could help to extend the useful life of organs intended for transplantation and provide an alternative therapy for patients with chronic kidney disease.

May 28, 2020February 18, 2019

IBEC researchers generate mini-kidneys vascularized from stem cells

Researchers from the IBEC have created, for the first time, 3D organoid cultures from pluripotent stem cells, which resemble human embryonic kidney tissue during the second trimester of pregnancy.

Using biomaterials that mimic the embryonic microenvironment, researchers have also achieved mini-kidneys with relevant features for immediate use in renal disease modeling.
A study published today in Nature Materials reports how researchers from IBEC have created organoids, or mini-organs, that resemble the human embryonic kidney, and how these 3D cultures mimic essential aspects during the formation of the kidney, such as distribution, functionality and specific organization of cells.