Biomedical signal processing and interpretation


Raimon Jané Campos | Group Leader
José Antonio Fiz Fernández | Senior Researcher
Beatriz Giraldo Giraldo | Senior Researcher
Jordi Solà Soler | Senior Researcher
Abel Torres Cebrián | Senior Researcher
Manuel Lozano García | Postdoctoral Researcher
Leonardo Sarlabous Uranga | Postdoctoral Researcher
Dolores Blanco Almazán | PhD Student
Luis Estrada Petrocelli | PhD Student
Javier Rodríguez Benítez | PhD Student
Yolanda Castillo Escario | Research Assistant
Josep Estévez Piorno | Masters Student
Borja Pérez Cengotitabengoa | Masters Student
Magdalena Ràfols de Urquía | Masters Student
María Rodríguez Cañón | Masters Student
Noelia Vaquero Gallardo | Masters Student

About

The group’s research addresses the design and development of advanced signal processing techniques and the interpretation of biomedical signals to improve non-invasive monitoring, diagnosis, disease prevention and pathology treatment.

Left: Improvement in Neural Respiratory Drive Estimation from Diaphragm Electromyographic Signals usingSample Entropy of non-invasive EMG signals (Estrada et al., 2016, IEEE Journal of Biomedical and Health Informatics).

Our main objective is to improve diagnosis capability through the characterization of physiological phenomena and to enhance early detection of major cardiac and respiratory diseases and sleep disorders. We propose and design new signal processing algorithms and develop new biosignal databases, with the collaboration of our hospital partners. To validate the clinical information of new surface signals, we have developed specific invasive/non-invasive protocols and animal models. The group focuses its research in a translational way to promote the transfer of our scientific and technological contributions. Currently, our prototypes are used in hospitals for research purposes and for future industrial developments.

Right: Novel method for differentiating normal from adventitious respiratory sounds (RS) to improve the diagnosis of pulmonary diseases. Particularly, continuous adventitious sounds (CAS) are of clinical interest because they reflect the severity of certain diseases. The new method is based on the multi-scale analysis of instantaneous frequency (IF) and envelope (IE) calculated after ensemble empirical mode decomposition (EEMD) of respiratory sounds. (Lozano et al., 2016, IEEE Journal of Biomedical and Health Informatics).

Highlights in 2016:

Obstructive Sleep Apnea and Sleep Disorders
– A novel method to analyse cardiorespiratory synchronization in OSA patients during sleep (IEEE-EMBC 2016, 4280-4283) and characterize snores (CASEIB 2016, 531-536), with the Hospital Germans Trias i Pujol, Badalona.

Chronic Obstructive Pulmonary Disease and Asthma
– Automatic detection of continuous adventitious respiratory sounds in asthmatic patients using ensemble empirical mode decomposition and instantaneous frequency (J Biomed Health Inf 2016, 20 (2): 486-497) and Hilbert-Huang transform (Signal Processing 2016, 120:99-116), with the Hospital Germans Trias i Pujol, Badalona (PhD thesis, M. Lozano).
– Non-invasive estimation of neural respiratory drive from diaphragm electromyographic signals using fixed sample entropy (J Biomed Health Inf 2016, 20 (2): 476-485); (PhD thesis, L. Estrada).
– Novel methods to estimate the respiratory muscle activity using wireless sensor platform (IEEE-EMBC 2016, 5769-5772, CASEIB 2016, 244-247 and CASEIB 2016, 556-559).
– Time-frequency representation of the sternocleidomastoid muscle activity during respiratory activity by electromyography recorded with concentric ring electrodes (IEEE-EMBC 2016, 3785-3788), with the Universidad Politécnica de Valencia.

Cardiac and cardiorespiratory diseases and ageing
– Evaluation of Periodic Breathing in Respiratory Flow Signal of Elderly Patients using SVM and Linear Discriminant Analysis (IEEE-EMBC 2016, 4276-4279).
– Estimation of blood pressure in patients with different ventricular ejection fraction using linear and non-linear methods (IEEE-EMBC 2016, 2700-2703) and characterization of patients with cardiovascular risk using Poincaré Plots (CASEIB 2016, 396-399), with Hospital Germans Trias i Pujol, Badalona and University of Jena, Germany.
– Analysis of ECG signal to risk stratification in patients with Parkinson disease (CASEIB 2016, 531-534).

Neurorehabilitation and Biofeedback
– Novel methods for analysis of the interlimb similarity of motor patterns for improving stroke assessment and neurorehabilitation (PhD thesis, O. Urra).

News/Jobs

Screening improvements for asthma and obstructive pulmonary disease patients
13/03/17

Some IBEC research published in PlosOne offers a step towards better screening of patients with asthma and other sufferers of obstructive pulmonary diseases.


Collaboration with clinicians leads to new non-invasive monitoring of COPD
01/02/16

A collaboration between IBEC’s Biomedical Signal Processing and Interpretation group and two local hospitals has resulted in a new non-invasive method of evaluating the efficiency of the respiratory muscles in patients with chronic obstructive pulmonary disease (COPD).


IBEC group leader in new CIBER-BBN steering committee
09/06/15

Biomedical Signal Processing and Interpretation group leader and UPC professor Raimon Jané has been appointed as a member of the new CIBER-BBN Steering Committee.


IBEC hosting CASEIB2014 this week
26/11/14

Today is the first day of the annual congress of the Sociedad Española de Ingeniería Biomédica (CASEIB 2014) which this year being organized by IBEC, as Biomedical Signal Processing and Interpretation group leader Raimon Jané is SEIB’s president. It is taking take place at Barcelona’s CosmoCaixa museum until Friday 28th November.


“Engineering Sleep Disorders”
30/09/14

An article by Raimon Jané appears in this month’s edition of IEEE Pulse, the magazine of the IEEE Engineering in Medicine and Biology Society, which is devoted to the science of sleep.


Sounds of health
10/04/14

A PLOS ONE article by researchers from the joint unit IBEC, the Fundació Institut Germans Trias i Pujol (IGTP) and the Pneumology Service at Germans Trias i Pujol University Hospital describes the acoustic analysis of pulmonary sound intensity as a non-invasive, more objective, easier and cheaper method to improve diagnostics in unilateral diaphragmatic paralysis.


Faster and more accurate testing for causes of lower respiratory tract infections
07/04/14

Research and industry collaboration develops miniature diagnostic platform for respiratory infections such as pneumonia and infectious bronchitis.


Every breath you take
19/02/14

New non-invasive monitoring will help patients with pathologies such as chronic obstructive pulmonary disease (COPD).


Measuring signals at the 11th “Recerca en directe” Science Fair
23/04/2013

IBEC’s Biomedical Signal Processing and Interpretation group took part in this year’s “Recerca en directe” science fair at La Pedrera, where they introduced an activity that helped visitors record and process their own biomedical signals.


“CASEIB 2012 celebrado en Donostia-San Sebastián”
12/03/2013

IBEC group leader Raimon Jané, in his role as president of the Sociedad Española de Ingeniería Biomédica (SEIB), features in a video about the society’s CASEIB 2012 annual meeting in San Sebastián in November.


“Raimon Jané, presidente de la Sociedad Española de Ingeniería Biomédica
01/03/2013

An interview with IBEC group leader Raimon Jané appears in the latest edition of CIBER-BBN’s newsletter.


Presidency of SEIB for IBEC group leader
05/12/2012

Biomedical signal processing and interpretation group leader Raimon Jané was elected as president of the Sociedad Española de Ingeniería Biomédica (SEIB) at its annual meeting (CASEIB) in San Sebastián.


“Separ y Ciber-BBN apuestan por la innovación”
19/06/2012

Last week Biomedical signal processing and interpretation group leader Raimon Jané was an invited speaker at a special institutional joint session of the CIBER-BBN (Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina) and SEPAR (Sociedad Española de Neumología y Cirugía Torácica) at SEPAR’s 45th National Meeting in Madrid.


IBEC signs collaboration agreements with IGTP
05/06/2012

Last week IBEC signed two collaboration agreements with the Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP) to carry out and promote scientific and translational research.


“System Automatically Monitors Apnea-Hypopnea Index”
18/04/2011

Some recent research by the Biomedical Signal Processing and Interpretation group has been featured in the section ‘Literature Review: A roundup of the most important recent studies’ in ENT Today magazine.

Projects

National projects
Multimodal invasive and non-invasive biomedical signal interpretation and modelling in cardiac, respiratory and neurological disorders MINECO, I+D-Investigación fundamental no orientada Raimon Jané
M-Bio4Health Biomarcadores fisiológicos multimodales para la monitorización no-invasiva y cuidado a domicilio de pacientes EPOC con comorbilidades MINECO, Retos investigación: Proyectos I+D Raimon Jané
Privately-funded projects
Study on software comparison of audio recordings and correlation to SAHS events Audiodontics LLC Raimon Jané
Novel m-Health tools for unobtrusive sensing and management improving of Obstructive Sleep Apnea patients at home Obra Social La Caixa Raimon Jané
CIBER-BBN Intramural projects
M-OLDOSA Multimodal analysis and m-Health tools for diagnostic and monitoring improving of Obstructive Lung Disease and Obstructive Sleep Apnea patients CIBER-BBN, Spain Raimon Jané
MultiTools2Heart Multiscale computational tools to improve diagnosis, risk assessment and treatment in prevalent heart diseases
CIBER-BBN, Spain Juan Pablo Martínez Cortés

Publications

Sarlabous, Leonardo, Torres, Abel, Fiz, José A., Martínez-Llorens, Juana M., Gea, Joaquim, Jané, Raimon, (2017). Inspiratory muscle activation increases with COPD severity as confirmed by non-invasive mechanomyographic analysis PLoS ONE 12, 5, e0177730

Lozano-García, M., Fiz, J. A., Martínez-Rivera, C., Torrents, A., Ruiz-Manzano, J., Jané, R., (2017). Novel approach to continuous adventitious respiratory sound analysis for the assessment of bronchodilator response PLoS ONE 12, 2, e0171455

Garde, A., Sörnmo, L., Laguna, P., Jané, R., Benito, S., Bayés-Genís, A., Giraldo, B. F., (2017). Assessment of respiratory flow cycle morphology in patients with chronic heart failure Medical and Biological Engineering and Computing 55, 2, 245-255

Estrada, L., Torres, A., Sarlabous, L., Jané, R., (2017). Onset and offset estimation of the neural inspiratory time in surface diaphragm electromyography: A pilot study in healthy subjects IEEE Journal of Biomedical and Health Informatics Epub ahead of print,

Lozano, Manuel, Fiz, J. A., Jané, Raimon, (2016). Performance evaluation of the Hilbert–Huang transform for respiratory sound analysis and its application to continuous adventitious sound characterization Signal Processing 120, 99-116

Lozano, M., Fiz, J. A., Jané, R., (2016). Automatic differentiation of normal and continuous adventitious respiratory sounds using ensemble empirical mode decomposition and instantaneous frequency IEEE Journal of Biomedical and Health Informatics 20, 2, 486-497

Estrada, L., Torres, A., Sarlabous, L., Jané, R., (2016). Improvement in neural respiratory drive estimation from diaphragm electromyographic signals using fixed sample entropy IEEE Journal of Biomedical and Health Informatics 20, 2, 476-485

Ramón Valencia, J. L., García-Sánchez, A., Roca-Dorda, J., Giraldo, B. F., (2016). Análisis de la señal ECG en pacientes con enfermedad de Párkinson CASEIB Proceedings Sociedad Española de Ingeniería Biomédica , 552-555

Arcentales, A., Rivera, P., Caminal, P., Voss, A., Bayés-Genís, A., Giraldo, B. F., (2016). Analysis of blood pressure signal in patients with different ventricular ejection fraction using linear and non-linear methods Engineering in Medicine and Biology Society (EMBC) IEEE , 2700-2703

Rodriguez, J., Voss, A., Caminal, P., Bayés-Genís, A., Giraldo, B. F., (2016). Caracterización de pacientes con diferentes niveles de riesgo cardiovascular mediante diagramas de Poincaré CASEIB Proceedings Sociedad Española de Ingeniería Biomédica , 396-399

Ràfols-de-Urquía, M., Estévez-Piorno, J., Torres, A., Estrada, L., Jané, R., (2016). Evaluación de un dispositivo inalámbrico para el registro de la actividad electromiográfica del músculo diafragma CASEIB Proceedings Sociedad Española de Ingeniería Biomédica , 244-247

Estévez-Piorno, J., Ràfols-de-Urquía, M., Torres, A., Estrada, L., Jané, R., (2016). Evaluación del registro y transmisión de señales electromiográficas mediante un dispostivo inalámbrico CASEIB Proceedings Sociedad Española de Ingeniería Biomédica , 556-559

Estrada, L., Torres, A., Sarlabous, L., Jané, R., (2016). Evaluating respiratory muscle activity using a wireless sensor platform Engineering in Medicine and Biology Society (EMBC) IEEE , 5769-5772

Argerich, S., Herrera, S., Benito, S., Giraldo, J., (2016). Evaluation of periodic breathing in respiratory flow signal of elderly patients using SVM and linear discriminant analysis Engineering in Medicine and Biology Society (EMBC) IEEE , 4276-4279

Julian, S., Callicó, F., Giraldo, B. F., Juanola, A., López, D., Rodiera, J., (2016). Segmentación del nodo vesical a partir del plano transversal de imágenes ecográficas de la región suprapúbica CASEIB Proceedings Sociedad Española de Ingeniería Biomédica , 278-281

Solà-Soler, J., Giraldo, B. F., Fiz, J. A., Jané, R., (2016). Study of phase estimation methods to analyse cardiorespiratory synchronization in OSA patients Engineering in Medicine and Biology Society (EMBC) IEEE , 4280-4283

Castillo, Y., Blanco, D., Cámara, M.A., Jané, R., (2016). Study of time-frequency characteristics of single snores: extracting new information for sleep apnea diagnosis CASEIB Proceedings Sociedad Española de Ingeniería Biomédica , 105-108

Estrada, L., Torres, A., Garcia-Casado, J., Sarlabous, L., Prats-Boluda, G., Jané, R., (2016). Time-frequency representations of the sternocleidomastoid muscle electromyographic signal recorded with concentric ring electrodes Engineering in Medicine and Biology Society (EMBC) IEEE , 3785-3788

Sarlabous, Leonardo, Torres, Abel, Fiz, José A., Gea, Joaquim, Martínez-Llorens, Juana M., Jané, Raimon, (2015). Efficiency of mechanical activation of inspiratory muscles in COPD using sample entropy European Respiratory Journal 46, 6, 1808-1811

Garde, A., Giraldo, B. F., Jané, R., Latshang, T. D., Turk, A. J., Hess, T., Bosch, M-.M., Barthelmes, D., Merz, T. M., Hefti, J. Pichler, Schoch, O. D., Bloch, K. E., (2015). Time-varying signal analysis to detect high-altitude periodic breathing in climbers ascending to extreme altitude Medical & Biological Engineering & Computing 53, 8, 699-712

Arcentales, A., Caminal, P., Diaz, I., Benito, S., Giraldo, B., (2015). Classification of patients undergoing weaning from mechanical ventilation using the coherence between heart rate variability and respiratory flow signal Physiological Measurement 36, 7, 1439-1452

Lozano, M., Fiz, J. A., Jané, R., (2015). Análisis de sonidos adventicios continuos en pacientes asmáticos mediante el espectro de Hilbert CASEIB Proceedings Sociedad Española de Ingeniería Biomédica , 179-182

Giraldo, B. F., Rodríguez, J., Arcentales, A., Voss, A., Caminal, P., Bayes-Genis, A., (2015). Caracterización de pacientes isquémicos y dilatados a partir de las señales ECG y de presión sanguínea CASEIB Proceedings Sociedad Española de Ingeniería Biomédica , 31-34

Giraldo, B. F., Rodriguez, J., Caminal, P., Bayes-Genis, A., Voss, A., (2015). Cardiorespiratory and cardiovascular interactions in cardiomyopathy patients using joint symbolic dynamic analysis Engineering in Medicine and Biology Society (EMBC) IEEE , 306-309

Sola-Soler, J., Giraldo, B. F., Fiz, J. A., Jané, R., (2015). Cardiorespiratory Phase Synchronization in OSA subjects during wake and sleep states Engineering in Medicine and Biology Society (EMBC) IEEE , 7708-7711

Estrada, L., Torres, A., Sarlabous, L., Jané, R., (2015). EMG-derived respiration signal using the fixed sample entropy during an Inspiratory load protocol Engineering in Medicine and Biology Society (EMBC) IEEE , 1703-1706

Estrada, L., Torres, A., Garcia-Casado, J., Sarlabous, L., Prats-Boluda, G., Jané, R., (2015). Evaluation of sternocleidomastoid muscle activity by electromyography recorded with concentric ring electrodes CASEIB Proceedings Sociedad Española de Ingeniería Biomédica , 183-186

Urra, O., Casals, A., Jané, R., (2015). The impact of visual feedback on the motor control of the upper-limb Engineering in Medicine and Biology Society (EMBC) IEEE , 3945-3948

Estrada, L., Torres, A., Sarlabous, L., Jané, R., (2015). Respiratory signal derived from the smartphone built-in accelerometer during a Respiratory Load Protocol Engineering in Medicine and Biology Society (EMBC) IEEE , 6768-6771

Urra, O., Casals, A., Jané, R., (2015). Visual feedback facilitates intermanual transfer of the motor control of the dominant arm towards the nondominant arm CASEIB Proceedings Sociedad Española de Ingeniería Biomédica , 503-506

Fiz, J. A., Jané, R., Lozano, M., Gómez, R., Ruiz, J., (2014). Detecting unilateral phrenic paralysis by acoustic respiratory analysis PLoS ONE 9, 4, e93595

Sarlabous, Leonardo, Torres, Abel, Fiz, J. A., Jané, Raimon, (2014). Evidence towards improved estimation of respiratory muscle effort from diaphragm mechanomyographic signals with cardiac vibration interference using sample entropy with fixed tolerance values PLoS ONE 9, 2, e88902

Jané, R., (2014). Engineering Sleep Disorders: From classical CPAP devices toward new intelligent adaptive ventilatory therapy IEEE Pulse 5, 5, 29-32

Lozano, M., Fiz, J., Jané, R., (2014). Análisis de la intensidad de los sonidos respiratorios para el diagnóstico de la parálisis frénica unilateral CASEIB Proceedings Sociedad Española de Ingeniería Biomédica , 1-4

Tellez, J. P., Herrera, S., Benito, S., Giraldo, B. F., (2014). Analysis of the breathing pattern in elderly patients using the hurst exponent applied to the respiratory flow signal Engineering in Medicine and Biology Society (EMBC) IEEE , 3422-3425

Estrada, Luis, Torres, Abel, Sarlabous, Leonardo, Fiz, Jose A., Gea, Joaquim, Martinez-Llorens, Juana, Jané, Raimon, (2014). Estimation of bilateral asynchrony between diaphragm mechanomyographic signals in patients with Chronic Obstructive Pulmonary Disease Engineering in Medicine and Biology Society (EMBC) IEEE , 3813-3816

Correa, L.S., Giraldo, B., Correa, R., Arini, P.D., Laciar, E., (2014). Estudio de la pausa espiratoria en pacientes con enfermedades obstructivas en proceso de desconexión de la ventilación mecánica IFMBE Proceedings Springer 49, 705-708

Giraldo, B., Chaparro, J. A., Caminal, P., Benito, S., (2014). Estudio de la potencia de la inspiración como predictor del proceso de extubación en pacientes CASEIB Proceedings Sociedad Española de Ingeniería Biomédica , 1-4

Téllez, J., Herrera, S., Benito, S., Giraldo, B., (2014). Estudio del patrón respiratorio en pacientes ancianos CASEIB Proceedings Sociedad Española de Ingeniería Biomédica , 1-4

Estrada, L., Torres, A., Jané, R., (2014). Evaluación de la asincronía bilateral y toracoabdominal mediante señales mecanomiográficas CASEIB Proceedings Sociedad Española de Ingeniería Biomédica , 1-4

Solà, J., Fiz, J.A., Torres, A., Jané, R., (2014). Evaluación de la vía aérea superior en sujetos con SAHS mediante análisis del sonido respiratorio durante vigilia CASEIB Proceedings Sociedad Española de Ingeniería Biomédica , 1-4

Estrada, L., Torres, A., Garcia-Casado, J., Prats-Boluda, G., Yiyao, Ye-Lin, Jané, R., (2014). Evaluation of Laplacian diaphragm electromyographic recording in a dynamic inspiratory maneuver Engineering in Medicine and Biology Society (EMBC) IEEE , 2201-2204

Solà, J., Fiz, J. A., Torres, A., Jané, R., (2014). Identification of Obstructive Sleep Apnea patients from tracheal breath sound analysis during wakefulness in polysomnographic studies Engineering in Medicine and Biology Society (EMBC) IEEE , 4232-4235

Chaparro, J. A., Giraldo, B. F., (2014). Power index of the inspiratory flow signal as a predictor of weaning in intensive care units Engineering in Medicine and Biology Society (EMBC) IEEE , 78-81

Sarlabous, L., Torres, A., Fiz, J.A., Gea, J., Martínez-Llorens, J.M., Jané, R., (2014). Relación entre la presión inspiratoria pico y la activación mecánica de los músculos inspiratorios durante respiración tranquila en pacientes con EPOC CASEIB Proceedings Sociedad Española de Ingeniería Biomédica , 1-4

Estrada, L., Torres, A., Sarlabous, L., Fiz, J. A., Jané, R., (2014). Respiratory rate detection by empirical mode decomposition method applied to diaphragm mechanomyographic signals Engineering in Medicine and Biology Society (EMBC) IEEE , 3204-3207

López Picazo, M., Solà, J., Fiz, J.A., Jané, R., (2014). Sincronización de sistemas de monitorización para el estudio de ronquidos en las distintas fases del sueño en pacientes con SAHS CASEIB Proceedings Sociedad Española de Ingeniería Biomédica , 1-4

Urra, O., Casals, A., Jané, R., (2014). Study of synergy patterns during the execution of stroke rehabilitation exercises CASEIB Proceedings Sociedad Española de Ingeniería Biomédica , 1-4

Urra, O., Casals, A., Jané, R., (2014). Synergy analysis as a tool to design and assess an effective stroke rehabilitation Engineering in Medicine and Biology Society (EMBC) IEEE , 3550-3553

Lozano, M., Fiz, J. A., Jané, R., (2014). Analysis of normal and continuous adventitious sounds for the assessment of asthma IFMBE Proceedings Springer International Publishing 41, 981-984

Giraldo, B. F., Calvo, A., Martínez, B., Arcentales, A., Jané, R., Benito, S., (2014). Blood pressure variability analysis in supine and sitting position of healthy subjects IFMBE Proceedings Springer International Publishing 41, 1021-1024

Torres, A., Fiz, J. A., Jané, R., (2014). Cancellation of cardiac interference in diaphragm EMG signals using an estimate of ECG reference signal IFMBE Proceedings Springer International Publishing 41, 1000-1004

Lambrecht, Stefan, Urra, Oiane, Grosu, Svetlana, Pérez, Soraya, (2014). Emerging rehabilitation in cerebral palsy Biosystems & Biorobotics Springer Berlin Heidelberg 4, 23-49

Urra, O., Casals, A., Jané, R., (2014). Evaluating spatial characteristics of upper-limb movements from EMG signals IFMBE Proceedings Springer International Publishing 41, 1795-1798

Estrada, L., Torres, A., Garcia-Casado, J., Ye-Lin, Y., Jané, R., (2014). Evaluation of Laplacian diaphragm electromyographic recordings in a static inspiratory maneuver IFMBE Proceedings Springer International Publishing 41, 977-980

Urra, O., Jané, R., (2014). New sleep transition indexes for describing altered sleep in SAHS IFMBE Proceedings Springer International Publishing 41, 1017-1020

Arizmendi, C., Viviescas, J., González, H., Giraldo, B., (2014). Patients classification on weaning trials using neural networks and wavelet transform IOS Press Volume 202, Integrating Information Technology and Management for Quality of Care, 107-110

Morgenstern, C., Randerath, W. J., Schwaibold, M., Bolz, A., Jané, R., (2013). Feasibility of noninvasive single-channel automated differentiation of obstructive and central hypopneas with nasal airflow Respiration 85, 4, 312-318

Sarlabous, L., Torres, A., Fiz, J. A., Morera, J., Jané, R., (2013). Index for estimation of muscle force from mechanomyography based on the Lempel-Ziv algorithm Journal of Electromyography and Kinesiology 23, 3, 548-557

Garde, Ainara, Voss, Andreas, Caminal, Pere, Benito, Salvador, Giraldo, Beatriz F., (2013). SVM-based feature selection to optimize sensitivity-specificity balance applied to weaning Computers in Biology and Medicine 43, 5, 533-540

Giraldo, B. F., Tellez, J. P., Herrera, S., Benito, S., (2013). Analysis of heart rate variability in elderly patients with chronic heart failure during periodic breathing CinC 2013 IEEE , 991-994

Sarlabous, L., Torres, A., Fiz, J. A., Jané, R., (2013). Cardiac interference reduction in diaphragmatic MMG signals during a Maintained Inspiratory Pressure Test Engineering in Medicine and Biology Society (EMBC) IEEE , 3845-3848

Estrada, L., Torres, A., Garcia-Casado, J., Prats-Boluda, G., Jané, R., (2013). Characterization of laplacian surface electromyographic signals during isometric contraction in biceps brachii Engineering in Medicine and Biology Society (EMBC) IEEE , 535-538

Arcentales, A., Voss, A., Caminal, P., Bayes-Genis, A., Domingo, M. T., Giraldo, B. F., (2013). Characterization of patients with different ventricular ejection fractions using blood pressure signal analysis CinC 2013 IEEE , 795-798

Giraldo, B. F., Chaparro, J. A., Caminal, P., Benito, S., (2013). Characterization of the respiratory pattern variability of patients with different pressure support levels Engineering in Medicine and Biology Society (EMBC) IEEE , 3849-3852

Lozano, M., Fiz, J. A., Jané, R., (2013). Estimation of instantaneous frequency from empirical mode decomposition on respiratory sounds analysis Engineering in Medicine and Biology Society (EMBC) IEEE , 981-984

Hernando, D., Alcaine, A., Pueyo, E., Laguna, P., Orini, M., Arcentales, A., Giraldo, B., Voss, A., Bayes-Genis, A., Bailon, R., (2013). Influence of respiration in the very low frequency modulation of QRS slopes and heart rate variability in cardiomyopathy patients CinC 2013 IEEE , 117-120

Gonzalez, H., Acevedo, H., Arizmendi, C., Giraldo, B. F., (2013). Methodology for determine the moment of disconnection of patients of the mechanical ventilation using discrete wavelet transform Complex Medical Engineering (CME) IEEE , 483-486

Jané, R., Lazaro, J., Ruiz, P., Gil, E., Navajas, D., Farre, R., Laguna, P., (2013). Obstructive Sleep Apnea in a rat model: Effects of anesthesia on autonomic evaluation from heart rate variability measures CinC 2013 IEEE , 1011-1014

Giraldo, B. F., Tellez, J. P., Herrera, S., Benito, S., (2013). Study of the oscillatory breathing pattern in elderly patients Engineering in Medicine and Biology Society (EMBC) IEEE , 5228-5231

Fiz, J. A., Jané, R., (2012). Snoring Analysis. A Complex Question Journal of Sleep Disorders: Treatment & Care 1, 1, 1-3

Mesquita, J., Solà, J., Fiz, J. A., Morera, J., Jané, R., (2012). All night analysis of time interval between snores in subjects with sleep apnea hypopnea syndrome Medical and Biological Engineering and Computing 50, 4, 373-381

Solà, J., Fiz, J. A., Morera, J., Jané, R., (2012). Multiclass classification of subjects with sleep apnoea-hypopnoea syndrome through snoring analysis Medical Engineering and Physics 34, 9, 1213-1220

Lozano, M., Fiz, J.A., Jané, R., (2012). Análisis multicanal de sonidos respiratorios en acústica pulmonar: aplicación clínica en pacientes asmáticos Libro de Actas XXX CASEIB 2012 Sociedad Española de Ingeniería Biomédica , 1-4

Giraldo, B.F., Gaspar, B.W., Caminal, P., Benito, S., (2012). Analysis of roots in ARMA model for the classification of patients on weaning trials Engineering in Medicine and Biology Society (EMBC) IEEE , 698-701

Urra, O., Fiz, J.A., Abad, J., Jané, R., (2012). Beyond the reach of AHI: identifying key markers for improved systematic diagnosis of SAHS Libro de Actas XXX CASEIB 2012 Sociedad Española de Ingeniería Biomédica , 1-4

Chaparro, J., Giraldo, B.F., Caminal, P., Benito, S., (2012). Comportamiento de parámetros del patrón respiratorio en clasificadores para la predicción del proceso weaning Libro de Actas XXX CASEIB 2012 Sociedad Española de Ingeniería Biomédica , 1-4

Garde, A., Laguna, P., Giraldo, B.F., Jané, R., Sörnmo, L., (2012). Ensemble-based time alignment of biomedical signals Proceedings BSI 2012 IEEE W3: METHODS FOR BIOMEDICAL SIGNAL PROCESSING ENHANCEMENT, 307-310

Garde, A., Giraldo, B.F., Jané, R., Latshang, T.D., Turk, A.J., Hess, T., Bosch, M-.M., Barthelmes, D., Hefti, J.P., Maggiorini, M., Hefti, U., Merz, T.M., Schoch, O.D., Bloch, K.E., (2012). Estudio de la respiración periódica en el ascenso a altitudes extremas a partir de la señal de volumen respiratorio Libro de Actas XXX CASEIB 2012 Sociedad Española de Ingeniería Biomédica , 1-4

Torres, A., Sarlabous, L., Fiz, J.A., Jané, R., (2012). Evaluación de diferentes algoritmos adaptativos para la atenuación de la interferencia cardiaca en señales mecanomiográficas simuladas Libro de Actas XXX CASEIB 2012 Sociedad Española de Ingeniería Biomédica , 1-4

Sarlabous, L., Torres, A., Fiz, J. A., Morera, J., Jané, R., (2012). Evaluation and adaptive attenuation of the cardiac vibration interference in mechanomyographic signals Engineering in Medicine and Biology Society (EMBC) IEEE , 3400-3403

Chaparro, J.A., Giraldo, B.F., Caminal, P., Benito, S., (2012). Performance of respiratory pattern parameters in classifiers for predict weaning process Engineering in Medicine and Biology Society (EMBC) IEEE , 4349-4352

Garde, A., Giraldo, B.F., Jané, R., Latshang, T.D., Turk, A.J., Hess, T., Bosch, M-.M., Barthelmes, D., Hefti, J.P., Maggiorini, M., Hefti, U., Merz, T.M., Schoch, O.D., Bloch, K.E., (2012). Periodic breathing during ascent to extreme altitude quantified by spectral analysis of the respiratory volume signal Engineering in Medicine and Biology Society (EMBC) IEEE , 707-710

Sarlabous, L., Torres, A., Fiz, J.A., Jané, R., (2012). Reducción de interferencia cardíaca en señales MMG diafragmáticas registradas durante un protocolo de carga incremental sostenida mediante el algoritmo RLS Libro de Actas XXX CASEIB 2012 Sociedad Española de Ingeniería Biomédica , 1-4

Mesquita, J., Poree, F., Carrault, G., Fiz, J. A., Abad, J., Jané, R., (2012). Respiratory and spontaneous arousals in patients with Sleep Apnea Hypopnea Syndrome Engineering in Medicine and Biology Society (EMBC) IEEE , 6337-6340

Yue, J. J., Morgenstern, R., Morgenstern, C., Lauryssen, C., (2011). Shape memory hydrogels - A novel material for treating age-related degenerative conditions of the Spine European Musculoskeletal Review 6, 3, 184-188

Morgenstern, R., Morgenstern, C., Jané, R., Lee, S. H., (2011). Usefulness of an expandable interbody spacer for the treatment of foraminal stenosis in extremely collapsed disks preliminary clinical experience with endoscopic posterolateral transforaminal approach Journal of Spinal Disorders & Techniques 24, 8, 485-491

Fiz, José Antonio, Solà, J., Jané, Raimon, (2011). Métodos de análisis del ronquido Medicina Clínica 137, 1, 36-42

Garde, A., Giraldo, B.F., Sornmo, L., Jané, R., (2011). Analysis of the respiratory flow cycle morphology in chronic heart failure patients applying principal components analysis Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society, 1725-1728

Chaparro, J.A., Giraldo, B.F. , Caminal, P., Benito, S., (2011). Analysis of the respiratory pattern variability of patients in weaning process using autoregressive modeling techniques Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society, 5690-5693

Solà, J., Fiz, J.A., Morera, J., Jané, R., (2011). Bayes classification of snoring subjects with and without Sleep Apnea Hypopnea Syndrome, using a Kernel method Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society, 6071-6074

Morgenstern, C., Schwaibold, M., Randerath, W., Bolz, A., Jané, R., (2011). Comparison of upper airway respiratory resistance measurements with the esophageal pressure/airflow relationship during sleep Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society, 3205-3208

Sarlabous, L., Torres, A., Fiz, J.A., Gea, J., Martinez-Llorens, J.M., Morera, J., Jané, R. , (2011). Evaluation of the respiratory muscles efficiency during an incremental flow respiratory test Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society, 3820-3823

Mesquita, J., Fiz, J.A., Solà, J., Morera, J., Jané, R., (2011). Normal non-regular snores as a tool for screening SAHS severity Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society, 3197-3200

Arcentales, A., Giraldo, B.F., Caminal, P., Benito, S., Voss, A., (2011). Recurrence quantification analysis of heart rate variability and respiratory flow series in patients on weaning trials Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society, 2724-2727

Jané, R., Fiz, J.A., Solà, J., Mesquita, J., Morera, J., (2011). Snoring analysis for the screening of sleep apnea hypopnea syndrome with a single-channel device developed using polysomnographic and snoring databases Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society, 8331-8333

Garde, A., Sörnmo, L., Jané, R., Giraldo, B., (2010). Breathing pattern characterization in chronic heart failure patients using the respiratory flow signal Annals of Biomedical Engineering 38, 12, 3572-3580

Caminal, P., Giraldo, B. F., Vallverdu, M., Benito, S., Schroeder, R., Voss, A., (2010). Symbolic dynamic analysis of relations between cardiac and breathing cycles in patients on weaning trials Annals of Biomedical Engineering 38, 8, 2542-52

Fiz, J. A., Jané, R., Solà, J., Abad, J., Garcia, M. A., Morera, J., (2010). Continuous analysis and monitoring of snores and their relationship to the apnea-hypopnea index Laryngoscope 120, 4, 854-862

Garde, A., Sörnmo, L., Jané, R., Giraldo, B. F., (2010). Correntropy-based spectral characterization of respiratory patterns in patients with chronic heart failure IEEE Transactions on Biomedical Engineering 57, 8, 1964-1972

Morgenstern, C., Schwaibold, M., Randerath, W. J., Bolz, A., Jané, R., (2010). An invasive and a noninvasive approach for the automatic differentiation of obstructive and central hypopneas IEEE Transactions on Biomedical Engineering 57, 8, 1927-1936

Garde, A., Schroeder, R., Voss, A., Caminal, P., Benito, S., Giraldo, B., (2010). Patients on weaning trials classified with support vector machines Physiological Measurement 31, 7, 979-993

Correa, R., Laciar, E., Arini, P., Jané, R., (2010). Analysis of QRS loop in the Vectorcardiogram of patients with Chagas' disease Engineering in Medicine and Biology Society (EMBC) IEEE , 2561-2564

Morgenstern, C., Schwaibold, M., Randerath, W., Bolz, A., Jané, R., (2010). Automatic non-invasive differentiation of obstructive and central hypopneas with nasal airflow compared to esophageal pressure Engineering in Medicine and Biology Society (EMBC) IEEE , 6142-6145

Garde, A., Sörnmo, L., Jané, R., Giraldo, B. F., (2010). Correntropy-based nonlinearity test applied to patients with chronic heart failure Engineering in Medicine and Biology Society (EMBC) IEEE , 2399-2402

Sarlabous, L., Torres, A., Fiz, J. A., Gea, J., Marti nez-Llorens, J. M., Morera, J., Jané, R., (2010). Interpretation of the approximate entropy using fixed tolerance values as a measure of amplitude variations in biomedical signals Engineering in Medicine and Biology Society (EMBC) IEEE , 5967-5970

Correa, L. S., Laciar, E., Mut, V., Giraldo, B. F., Torres, A., (2010). Multi-parameter analysis of ECG and Respiratory Flow signals to identify success of patients on weaning trials Engineering in Medicine and Biology Society (EMBC) IEEE -----, 6070-6073

Leder, R. S., Schlotthauer, G., Penzel, T., Jané, R., (2010). The natural history of the sleep and respiratory engineering track at EMBC 1988 to 2010 Engineering in Medicine and Biology Society (EMBC) IEEE , 288-291

Torres, A., Sarlabous, L., Fiz, j A., Gea, J., Marti nez-Llorens, J. M., Morera, J., Jané, R., (2010). Noninvasive measurement of inspiratory muscle performance by means of diaphragm muscle mechanomyographic signals in COPD patients during an incremental load respiratory test Engineering in Medicine and Biology Society (EMBC) IEEE , 2493-2496

Mesquita, J., Fiz, J. A., Solà, J., Morera, J., Jané, R., (2010). Regular and non regular snore features as markers of SAHS Engineering in Medicine and Biology Society (EMBC) IEEE , 6138-6141

Arcentales, A., Giraldo, B. F., Caminal, P., Diaz, I., Benito, S., (2010). Spectral analysis of the RR series and the respiratory flow signal on patients in weaning process Engineering in Medicine and Biology Society (EMBC) IEEE , 2485-2488

Estrada, L., Santamaria, J., Isetta, V., Iranzo, A., Navajas, D., Farre, R., (2010). Validation of an EEG-based algorithm for automatic detection of sleep onset in the multiple sleep latency test Proceedings of the World Congress on Engineering 2010 IAENG (International Association of Engineers) 1, 1-3

Fiz, J. A., Morera Prat, J., Jané, R., (2009). Treatment of patients with simple snoring Archivos de Bronconeumología 45, 10, 508-515

Morgenstern, C., Schwaibold, M., Randerath, W. J., Bolz, A., Jané, R., (2009). Assessment of changes in upper airway obstruction by automatic identification of inspiratory flow limitation during sleep IEEE Transactions on Biomedical Engineering 56, 8, 2006-2015

Correa, R., Laciar, E., Arini, P., Jané, R., (2009). Analysis of QRS loop changes in the beat-to-beat vectocardiogram of ischemic patients undergoing PTCA Engineering in Medicine and Biology Society (EMBC) IEEE , 1750-1753

Diez, P. F., Mut, V., Laciar, E., Torres, A., Avila, E., (2009). Application of the empirical mode decomposition to the extraction of features from EEG signals for mental task classification Engineering in Medicine and Biology Society (EMBC) IEEE , 2579-2582

Morgenstern, C., Schwaibold, M., Randerath, W., Bolz, A., Jané, R., (2009). Automatic differentiation of obstructive and central hypopneas with esophageal pressure measurement during sleep Engineering in Medicine and Biology Society (EMBC) IEEE 2009, 7102-7105

Garde, A., Sornmo, L., Jané, R., Giraldo, B. F., (2009). Correntropy-based analysis of respiratory patterns in patients with chronic heart failure Engineering in Medicine and Biology Society (EMBC) IEEE , 4687-4690

Arizmendi, C., Romero, E., Alquezar, R., Caminal, P., Díaz, I., Benito, S., Giraldo, B. F., (2009). Data mining of patients on weaning trials from mechanical ventilation using cluster analysis and neural networks Engineering in Medicine and Biology Society (EMBC) IEEE , 4343-4346

Orosco, L., Laciar, E., Correa, A. G., Torres, A., Graffigna, J. P., (2009). An epileptic seizures detection algorithm based on the empirical mode decomposition of EEG Engineering in Medicine and Biology Society (EMBC) IEEE , 2651-2654

Sarlabous, L., Torres, A., Fiz, J. A., Gea, J., Martinez-Llorens, J. M., Jané, R., (2009). Evaluation of the respiratory muscular function by means of diaphragmatic mechanomyographic signals in COPD patients Engineering in Medicine and Biology Society (EMBC) IEEE , 3925-3928

Sarlabous, L., Torres, A., Fiz, J. A., Gea, J., Galdiz, J. B., Jané, R., (2009). Multistate Lempel-Ziv (MLZ) index interpretation as a measure of amplitude and complexity changes Engineering in Medicine and Biology Society (EMBC) IEEE , 4375-4378

Correa, L. S., Laciar, E., Mut, V., Torres, A., Jané, R., (2009). Sleep apnea detection based on spectral analysis of three ECG - Derived respiratory signals Engineering in Medicine and Biology Society (EMBC) IEEE , 4723-4726

Correa, R., Arini, P. D., Laciar, E., Laguna, P., Jané, R., (2009). Study of morphological parameters of QRS loop using singular value decomposition during ischemia induced by coronary angioplasty 36th Annual Computers in Cardiology Conference (CinC) IEEE 36, 693-696

Garde, A., Giraldo, B. F., Jané, R., Sornmo, L., (2009). Time-varying respiratory pattern characterization in chronic heart failure patients and healthy subjects Engineering in Medicine and Biology Society (EMBC) IEEE , 4007-4010

Seeck, A., Garde, A., Schuepbach, M., Giraldo, B., Sanz, E., Huebner, T., Caminal, P., Voss, A., (2009). Diagnosis of ischemic heart disease with cardiogoniometry - linear discriminant analysis versus support vector machines IFMBE Proceedings Springer Berlin Heidelberg 22, 389-392

Morgenstern, C., Jané, R., Schwaibold, M., Randerath, W., (2008). Automatic classification of inspiratory flow limitation assessed non-invasively during sleep IEEE Engineering in Medicine and Biology Society Conference Proceedings IEEE 1-8, 1132-1135

Morgenstern, C., Jané, R., Schwaibold, M., Randerath, W., (2008). Characterization of inspiratory flow limitation during sleep with an exponential model IEEE Engineering in Medicine and Biology Society Conference Proceedings IEEE 1-8, 2439-2442

Garde, A., Giraldo, B. F., Jané, R., Diaz, I., Herrera, S., Benito, S., Domingo, M., Bayes-Genis, A., (2008). Characterization of periodic and non-periodic breathing pattern in chronic heart failure patients IEEE Engineering in Medicine and Biology Society Conference Proceedings IEEE 1-8, 3227-3230

Diez, Pablo F., Laciar, Eric, Mut, Vicente, Avila, Enrique, Torres, Abel, (2008). A comparative study of the performance of different spectral estimation methods for classification of mental tasks IEEE Engineering in Medicine and Biology Society Conference Proceedings IEEE 1-8, 1155-1158

Solà, J., Jané, R., Fiz, J. A., Morera, J., (2008). Formant frequencies of normal breath sounds of snorers may indicate the risk of obstructive sleep apnea syndrome IEEE Engineering in Medicine and Biology Society Conference Proceedings IEEE 1-8, 3500-3503

Correa, L. S., Laciar, E., Torres, A., Jané, R., (2008). Performance evaluation of three methods for respiratory signal estimation from the electrocardiogram IEEE Engineering in Medicine and Biology Society Conference Proceedings IEEE 1-8, 4760-4763

Torres, A., Fiz, J. A., Jané, R., Laciar, E., Galdiz, J. B., Gea, J., Morera, J., (2008). Renyi entropy and Lempel-Ziv complexity of mechanomyographic recordings of diaphragm muscle as indexes of respiratory effort IEEE Engineering in Medicine and Biology Society Conference Proceedings IEEE 1-8, 2112-2115

Orini, Michele, Giraldo, Beatriz F., Bailon, Raquel, Vallverdu, Montserrat, Mainardi, Luca, Benito, Salvador, Diaz, Ivan, Caminal, Pere, (2008). Time-frequency analysis of cardiac and respiratory parameters for the prediction of ventilator weaning IEEE Engineering in Medicine and Biology Society Conference Proceedings IEEE 1-8, 2793-2796

Equipment

  • Research laboratory with full equipment for acquisition and processing of biomedical signal to test new sensors and to define clinical protocols (preliminary tests and control subjects)
  • Non-invasive Vital Signs Monitor for small lab animals (mice and rats) (Mouse-Ox Plus)
  • BIOPAC system for multichannel cardiac and respiratory biomedical signal acquisition
  • Databases of biomedical signals from hospitals and animal laboratories
  • Snoring analyzer equipment (SNORYZER)
  • Sensors, electrodes and microphones to obtain cardiac, respiratory, neural, muscular and sleep biomedical signals
  • Polisomnographic equipment available in the Sleep Laboratory of collaborator hospital
  • Beat to beat arterial blood pressure and haemodynamic monitor equipment
  • Computing server for high performance biomedical signals
  • Threshold™ IMT (Inspiratory Muscle Trainner) for respiratory muscle training (Phillips™)
  • Robust wearable wireless sensor device Shimmer3 (Shimmer Research Ltd., Dublin, Ireland).

Collaborations

  • Dr. J. Mark Ansermino
    Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada
  • Prof. Antonio Bayes Genis
    Grup ICREC, Servei Cardiología Hospital Universitari Germans Trias i Pujol, Barcelona
  • Dr. Salvador Benito
    Hospital de la Santa Creu i Sant Pau, Barcelona
  • Prof. Dr. Konrad Bloch
    Pulmonary Division, University of Zurich, Switzerland
  • Prof. Armin Bolz
    Institute of Biomedical Engineering, University of Karlsruhe, Germany
  • Prof. Manuel Doblaré
    Grupo de Mecánica Estructural y Modelado de Materiales, Universidad de Zaragoza, Spain
  • Prof. Guy Dumont
    Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada
  • Prof. Ramon Farré
    Unitat de Biofísica i Bioenginyeria, Facultat de Medicina, Barcelona
  • Dr. Javier García-Casado
    Instituto Interuniversitario de Investigación en Bioingeniería y Tecnología Orientada al Ser Humano, Universidad Politécnica de Valencia
  • Dr. Joaquim Gea
    Servei Pneumologia, Hospital del Mar-IMIM, Barcelona
  • Dr. Alfredo Hernández
    Laboratoire Trataiment du Signal et de l’Image, Université de Rennes 1, Instituto Francés de Salud (INSERM), France
  • Dr. Eric Laciar
    Departamento de Electrónica y Automática, Universidad Nacional de San Juan, Argentina
  • Prof. Pablo Laguna
    Instituto de Investigación de Aragón (I3A), Universidad de Zaragoza, Spain
  • Dr. Barry Mersky
    Audiodontics, LLC, Bethesda, Maryland, USA
  • Prof. Dr. Thomas Penzel
    Interdisciplinary Sleep Center, Charité University Hospital, Berlin, Germany
  • Dr. Josep Morera Prat
    Servicio de Neumología, Hospital Germans Trias i Pujol, Badalona, Spain
  • Prof. Winfried J. Randerath
    Institut für Pneumologie, Klinik Bethanien, Solingen, Germany
  • Dr. Juan Ruiz
    Servei de Pneumología de l’Hospital Germans Trias i Pujol de Badalona
  • Dr. Matthias Schwaibold
    MCC-Med GmbH & Co. KG, Karlsruhe, Germany
  • Prof. Dr. Lotfi Senhadji
    Laboratoire Traitement du Signal et de l’Image (LTSI), Université de Rennes 1, Institut National de la Santé et de la Recherche Médicale (INSERM), France
  • Prof. Leif Sörnmo
    Signal processing group, Lund University, Sweden
  • Prof. Dr. Jaume Veciana
    Grupo de Nanociencia Molecular y Materiales Orgánicos del Instituto de Ciencia de Materiales de Barcelona (NANOMOL-CSIC), Barcelona
  • Prof. Andreas Voss
    University of Applied Sciences, Jena, Germany
  • Dr. Pierluigi Casale
    Laboratory for advanced research in microelectronics (IMEC), Eindhoven, The Netherlands
  • Dr. Francky Catthoor
    Laboratory for advanced research in microelectronics (IMEC), Leuven, Belgium
  • Dr. Miquel Domenech
    Dep. of Social Psychology, Universitat Autònoma de Barcelona
  • Dr. Caroline Jolley / Dr. John Moxham
    King’s College London, UK

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