by Keyword: Magnetic nanoparticle
Gallo, J, Villasante, A, (2023). Recent Advances in Biomimetic Nanocarrier-Based Photothermal Therapy for Cancer Treatment International Journal Of Molecular Sciences 24, 15484 
Nanomedicine presents innovative solutions for cancer treatment, including photothermal therapy (PTT). PTT centers on the design of photoactivatable nanoparticles capable of absorbing non-toxic near-infrared light, generating heat within target cells to induce cell death. The successful transition from benchside to bedside application of PTT critically depends on the core properties of nanoparticles responsible for converting light into heat and the surface properties for precise cell-specific targeting. Precisely targeting the intended cells remains a primary challenge in PTT. In recent years, a groundbreaking approach has emerged to address this challenge by functionalizing nanocarriers and enhancing cell targeting. This strategy involves the creation of biomimetic nanoparticles that combine desired biocompatibility properties with the immune evasion mechanisms of natural materials. This review comprehensively outlines various strategies for designing biomimetic photoactivatable nanocarriers for PTT, with a primary focus on its application in cancer therapy. Additionally, we shed light on the hurdles involved in translating PTT from research to clinical practice, along with an overview of current clinical applications.
JTD Keywords: biomimetic nanoparticles, cancer treatment, diagnosis, drug-delivery, erythrocyte-membrane, facile synthesis, iron-oxide nanoparticles, magnetic nanoparticles, membrane-camouflaged nanoparticles, metastatic breast-cancer, size, stem-cells, Biomimetic nanoparticles, Cancer treatment, Membrane-camouflaged nanoparticles, Photothermal therapy
Apriceno, A, Silvestro, I, Girelli, A, Francolini, I, Pietrelli, L, Piozzi, A, (2021). Preparation and characterization of chitosan-coated manganese-ferrite nanoparticles conjugated with laccase for environmental bioremediation Polymers 13, 1453
Bioremediation with immobilized enzymes has several advantages, such as the enhancement of selectivity, activity, and stability of biocatalysts, as well as enzyme reusability. Laccase has proven to be a good candidate for the removal of a wide range of contaminants. In this study, naked or modified MnFe O magnetic nanoparticles (MNPs) were used as supports for the immobilization of laccase from Trametes versicolor. To increase enzyme loading and stability, MNPs were coated with chitosan both after the MNP synthesis (MNPs-CS) and during their formation (MNPs-CS ). SEM analysis showed different sizes for the two coated systems, 20 nm and 10 nm for MNPs-CS and MNPs-CS , respectively. After covalent immobilization of laccase by glutaraldehyde, the MNPs-CS -lac and MNPs-CS-lac systems showed a good resistance to temperature denaturation and storage stability. The most promising system for use in repeated batches was MNPs-CS -lac, which degraded about 80% of diclofenac compared to 70% of the free enzyme. The obtained results demonstrated that the MnFe O -CS system could be an excellent candidate for the removal of contaminants. 2 4 in situ in situ in situ in situ 2 4 in situ
JTD Keywords: bioremediation, chitosan, diclofenac, diclofenac removal, immobilized enzyme, laccase, magnetic nanoparticles, phase, removal, supports, Bioremediation, Chitosan, Diclofenac removal, Enzyme immobilization, Immobilized enzyme, Laccase, Magnetic nanoparticles
Riggio, C., Nocentini, S., Catalayud, M. P., Goya, G. F., Cuschieri, A., Raffa, V., del Río, J. A., (2013). Generation of magnetized olfactory ensheathing cells for regenerative studies in the central and peripheral nervous tissue International Journal of Molecular Sciences 14, (6), 10852-10868
As olfactory receptor axons grow from the peripheral to the central nervous system (CNS) aided by olfactory ensheathing cells (OECs), the transplantation of OECs has been suggested as a plausible therapy for spinal cord lesions. The problem with this hypothesis is that OECs do not represent a single homogeneous entity, but, instead, a functionally heterogeneous population that exhibits a variety of responses, including adhesion and repulsion during cell-matrix interactions. Some studies report that the migratory properties of OECs are compromised by inhibitory molecules and potentiated by chemical gradients. In this paper, we report a system based on modified OECs carrying magnetic nanoparticles as a proof of concept experiment enabling specific studies aimed at exploring the potential of OECs in the treatment of spinal cord injuries. Our studies have confirmed that magnetized OECs (i) survive well without exhibiting stress-associated cellular responses; (ii) in vitro, their migration can be modulated by magnetic fields; and (iii) their transplantation in organotypic slices of spinal cord and peripheral nerve showed positive integration in the model. Altogether, these findings indicate the therapeutic potential of magnetized OECs for CNS injuries.
JTD Keywords: Magnetic nanoparticle, Nerve regeneration, Olfactory ensheathing cell, Organotypic culture
