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Protein phase transitions in health and disease

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IBEC and Antoni Muntadas featured in the ‘Invisible Animals’ exhibition at the Natural Science Museum of Barcelona

The Institute for Bioengineering of Catalonia (IBEC) attended the opening of the exhibition, which highlights extinct fauna that remains present in the collective imagination. The exhibition includes a section dedicated to the Tasmanian tiger featuring a piece by Antoni Muntadas, on which IBEC collaborated with Benedetta Bolognesi, a principal investigator at the institute.

Seven additional IBEC labs achieve top-level in My Green Lab certification

Seven more research groups at the Institute for Bioengineering of Catalonia (IBEC) have been certified by My Green Lab, reaching the highest rating, the Green Level, for sustainable laboratory practices. With these additions, IBEC core facilities and 70% of the Institute’s laboratories are now certified.

Scientists map the first step in Alzheimer’s protein aggregation and discover clues for future therapies

This is an analysis on an unprecedented scale. They studied over 140,000 versions of the Aβ42 peptide, which forms harmful plaques in the brain. It is the first map to reveal how mutations affect a protein in its transition state — a fleeting phase that is difficult to study. This finding opens up new avenues for preventing Alzheimer’s disease and suggests a method that can be applied to studying other proteins involved in different pathologies. The study, published in Science Advances, is a collaboration between the Wellcome Sanger Institute in the United Kingdom, the Institute for Bioengineering of Catalonia, and the Centre for Genomic Regulation in Barcelona.

“Explainable” AI cracks secret language of sticky proteins

The new AI is able to predict when and why protein aggregation occurs, a mechanism linked to Alzheimer’s and 50 other diseases that affect 500 million people. The results show great potential for research into neurodegenerative diseases and for improving drug production, reducing costs and increasing efficiency. The study, published today in Science Avances, is the result of a collaboration between the Centre for Genomic Regulation (CRG) and the Institute of Bioengineering of Catalonia (IBEC).

Three IBEC researchers selected in the CaixaResearch 2024 call to lead health research projects

IBEC researchers Benedetta Bolognesi, Xavier Fernàndez Busquets and Xavier Trepat have been selected in the CaixaResearch 2024 call to lead their own research projects. The grants will provide financial support for the scientists to carry out their research in key areas such as cancer, malaria and amyotrophic lateral sclerosis.

Benedetta Bolognesi awarded a prestigious European ERC Consolidator Grant

The researcher at the Institute for Bioengineering of Catalonia has been awarded an ERC Consolidator Grant. This prestigious European funding supports excellent scientists and scholars who are consolidating their independent research teams to pursue their most promising scientific ideas. The €2 million grant over 5 years will allow Bolognesi and her team to develop a new method for identifying mutations that lead to the formation of amyloids—aggregates of proteins that contribute to a variety of diseases, including Alzheimer’s and Parkinson’s.

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