An unprecedented mutation map reveals how amylin mutations influence type 2 diabetes
A study by the Institute for Bioengineering of Catalonia (IBEC) has created a mutational map of the hormone amylin, the aggregation of which can damage pancreatic cells and lead to type 2 diabetes. The team analysed 1,916 variants of the protein and compared the results of this mutational map with genetic and clinical data from 500,000 individuals. The study, published in Nature Communications, sheds new light on the role of genetics in diabetes and could lead to the development of safer and more effective drugs.