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Unlocking the potential of human organoids through bioengineering

In a new review published in the prestigious scientific journal Nature Materials, IBEC experts discuss together with international experts from USA and Europe how bioengineering could be applied for the presentation of external inputs to better guide self-organisation and differentiation of human pluripotent stem cells (hPSCs) in order to generate higher-grade organoids

Bioengineering to fight Covid-19

Yesterday took place the kick-off meeting of the european project MAD-CoV 2, in which participates the group led by ICREA Research Professor Núria Montserrat at IBEC.

Under the name of “Modern approaches for developing antivirals against SARS-CoV 2” (MAD-CoV 2) the project focuses on the development and delivery of therapeutic tools for the current COVID-19 outbreak.

Bioengineering contributes to new advances against childhood cancer

IBEC contributes to elucidate how the rigidity of the tumor extracellular matrix affects the aggressiveness of neuroblastoma, a cancerous tumor that affects mainly children. This opens the door to generate more accurate models to predict tumor development in patients and to work in the design of new treatments.

Neuroblastoma is the most frequent malignant tumor in the first year of life. It is caused by a genetic mutation from immature nerve cells (neuroblasts) that the fetus produces as part of its development process.

Identified a new repairing mechanism of the peripheral nervous system by applyting bioengineering techniques

The Molecular and cellular neurobiotechnology group with the collaboration of the Nanobioengineering group, both of them at IBEC, have applied a new light-stimulated technique to modulate muscular activity and stimulate cell regeneration of the peripheral nervous system.

Thanks to this research they have discovered that muscle activity can activate the neurons and accelerate their regeneration after an injury.

Researchers at IBEC develop a bioengineering platform to detect pro-inflammatory molecules in muscular disorders

The Biosensors for bioengineering group led by Javier Ramón has developed a sensing platform for the in-situ detection of tissue-secreted pro-inflammatory molecules, the so-called cytokines. This new methodology opens a new door in the understanding of metabolic-disorders such those found in muscular diseases, as well as the development of drug-screening applications.

Although 40% of total body mass is skeletal muscle tissue, there is no specialized clinical doctor for the treatment of muscular diseases, according to the American Medical Association. The research group of Dr. Javier Ramón at IBEC works to fill this gap between muscle disorders and ad hoc therapies.

Reaching new depths: a non-invasive solution for the activation of proteins in deep tissues

Researchers at IBEC and their collaborators at the Centre of Regenerative Medicine of Barcelona (CMR[B]) have developed a revolutionary new technique based on photoactivation (light activation), by which cells in deep tissue can activated and tracked in vivo without causing any damage.

Manipulating protein expression to monitor cell behavior is a powerful tool in the field of biology.