Research news Archives - Page 18 of 31 - Institute for Bioengineering of Catalonia

May 28, 2020February 8, 2018

A mechanism that regulates neurogenesis in the adult brain

Scientists from IBEC’s Molecular and Cellular Neurobiotechnology group have discovered a protein and its receptor that control the spread of adult stem cells in the hippocampus, the part of the brain responsible for memory.

The discovery could shed light on the mechanisms involved in memory, the development of neurodegenerative diseases such as Alzheimers, or in the development of brain tumors caused by the uncontrolled proliferation of various cell types.

February 5, 2018

Obesity study on front cover of Proteomics – Clinical Applications

Researchers working at the Signal and Information Processing for Sensing Systems group and at the Nestlé Institute of Health Sciences have published a study selected as the front cover of a special issue of the journal Proteomics: Clinical Applications.

The paper, whose first author is PhD student Sergio Oller, identifies proteins associated with weight loss and maintenance, and explores their relation to body mass index, fat mass, and insulin resistance and sensitivity, identifying potential biomarkers for weight loss and maintenance.

May 28, 2020January 19, 2018

A material that encourages blood vessels to form

In a further step forward in their quest to achieve functional biomaterials for tissue regeneration, IBEC’s Biomaterials for Regenerative Therapies group has revealed a new construct that enhances blood vessel formation and maturation in vivo.

In the paper published in Acta Biomaterialia at the end of last year, the group and their collaborators at the Georgia Institute of Technology present a new implantable hydrogel that contains both human mesenchymal stromal cells (hMSCs) and calcium-releasing microparticles.

May 28, 2020January 17, 2018

Nanomotors can be propelled by light

Researchers working at IBEC and the Max Planck Institute for Intelligent Systems have developed nanomotors that are powered by a fuel-free, biofriendly and unlimited power source: light.

May 28, 2020December 28, 2017

How perception shapes our actions

Last Saturday, another “Classico” saw Messi and Ronaldo display their other-worldly skills and ball control. At the heart of their performance stands the amazing ability to control their bodies in anticipation of the movements of their team members, opponents – and especially the football.

These anticipatory motor actions are essential for sport, but also underlie our everyday behavior, from walking or grasping to riding a bicycle or typing on a keyboard. But how exactly are these actions controlled?

May 28, 2020December 20, 2017

A molecular mechanism could explain how bacteria resist antibiotics

IBEC researchers have shown for the first time how bacteria make DNA under stressful conditions, such as drug treatments.

This new knowledge could help develop new antibiotics that work, tackling the urgent problem of antibiotic resistance.

The Bacterial infections: antimicrobial therapies group led by Dr. Eduard Torrents was studying the bacterial strain Pseudomonas aeruginosa, which can cause severe chronic lung infections in cystic fibrosis (CF) patients, leading to severely impaired lung function, an increased risk of respiratory failure, and death.

May 28, 2020December 15, 2017

Enzyme-powered nanomotors deliver anti-cancer drugs more efficiently

IBEC researchers have demonstrated that their enzyme-powered nanobots show a marked improvement in drug delivery efficiency over passive ones.

The Advanced Functional Materials paper is the result of two years of work at IBEC, where Samuel Sanchez’s group has been experimenting with enzyme catalysis to power micro- and nanomotors. By consuming biocompatible fuels, these nanoparticles can then be used for biomedical applications such as targeted drug delivery to cancer cells.

May 28, 2020December 11, 2017

Cells feel their environment to explore it

The way cells find their way around is by ‘groping’ rather than seeing their surroundings: this is the main conclusion of a study published in Nature last week involving several IBEC groups and their collaborators.

“We determined how cells detect the position of molecules (or ligands) in their environment with nanometric accuracy,” explains Pere Roca-Cusachs, group leader at IBEC and assistant professor at the University of Barcelona, who led the study. “By adhering to the ligands, the cells apply a force they can detect. As this force depends on the spatial distribution of the ligands, this allows the cells to ‘feel’ their surroundings. It’s like recognizing somebody’s face in the dark by touching it with your hand, rather than seeing the person.”

June 9, 2020December 4, 2017

Deciphering cell language

New insights into the intercellular communications mechanism that regulates cell repositioning leads the way towards the development of targeted therapies in regenerative medicine

Understanding the language of cells in order to redirect them when necessary: this is one possibility unveiled by researchers at the Center for Regenerative Medicine of Barcelona (CMR[B]), led by Dr. Samuel Ojosnegros, who describe in their latest paper the intercellular communications mechanism involved in cell relocation.

The work, published in Proceedings of the National Academy of Sciences (PNAS), was carried out in collaboration with the groups of Elena Martínez (IBEC) and Melike Lakadamyali (ICFO), among others. The fruitful collaboration also gave rise to the publication of work by Verónica Hortigüela, former PhD student in Elena’s group, who bioengineered a nanopatterning strategy that provides control over this communication mechanism.

December 1, 2017November 30, 2017

IBEC researchers make an electrical contact out of a single protein

IBEC’s Nanoprobes and Nanoswitches group have designed a single-protein electrical contact which can efficiently transfer an electrical charge.

Through a subtle mutation in a copper protein which is responsible for various metabolic redox processes in the bacterium Pseudomona aeruginosa, they managed to control the transport of electrons in the biomolecule.