Detecting lung infections with breath analysis and machine learning

IBEC researchers, together with clinicians from Sant Pau Hospital and Hospital Clinic in Barcelona, use “electronic noses” and machine learning to analyse the breath of patients, identifying with high accuracy those with lung infections of P. aeruginosa, a multidrug resistant pathogen. This method could represent a non-invasive and efficient tool to diagnose and monitor patients with a bacterial lung infection, offering a faster alternative to standard sputum cultures.

Reducing animal testing with 3D Bioprinting: European project BRIGHTER brings new light

The European project BRIGHTER, coordinated by IBEC, is developing a new technology to produce functional human tissues as an alternative to animal experimentation in the field of biomedical research. This light-based 3D bioprinting technology fabricates tissues by patterning three-dimensional cell cultures. In the future, it could be even used to produce organs in the laboratory.

Unraveling the cell’s sweet spot from nature

In a recent Nature chemical biology paper, a team of researchers from ICMS/TUE and IBEC, together with researchers from Leiden University unravel the interactions of individual sugar molecules with cells using super-resolution microscopy. The paper appeared on the cover of the November issue of the journal.

Electronic nose on a drone sniffs out wastewater plant stink

Researchers from Spain have engineered a portable electronic nose (e-nose) that’s almost as sharp as a human nose at sniffing out wastewater treatment plants’ stink. Coupled with a drone, the lightweight e-nose can measure the concentration of different smells, predict odor intensity and produce a real-time odor map of the plant for management. The method developed was published November 16 in the journal iScience.

Researchers discover how cellular membranes change curvature depending on BAR proteins

A team of researchers at IBEC and UPC, led by Pere Roca-Cusachs and Marino Arroyo, study how BAR proteins, a family of molecules that bind curved cellular membranes, reshape these membranes. Scientists report in the journal Nature Communications, through both experiments and modelling, the dynamics of these membrane reshaping processes that occur both in normal cells or disease scenarios.

‘Dancing molecules’ repair severe spinal cord injuries in paralyzed animals

Researchers from the University of Northwestern, in the United States, and the Institute of Bioengineering of Catalonia (IBEC), develop a new injectable therapy that uses synthetic nanofibers to repair spinal cord lesions. Nanofibers, which contain ‘Dancing molecules’ effectively stimulate cellular receptors by promoting spinal cord regeneration. After a single injection, paralyzed animals treated with this new therapy were able to walk again in just four weeks. The article has been published in Science. 

Artificial smell to control food quality

Researchers from IBEC, in collaboration with the University of Cordoba, recently published a study where they develop protocols that optimize the use of a technique capable of analysing, at the molecular level, substances present in the aroma of food, managing to differentiate samples of ham from Iberian pigs fed with acorn or feed. This new approach, which uses artificial intelligence to analyse the data, will simplify the analysis of aromas, and can be very useful to determine the traceability and quality of food, and fight against fraud.

RAS gene and tissue physics act in tandem to drive cancer processes

Researchers from IBEC, the UCL (UK), UPC (Spain) and the TU/e (Netherlands) show that activation of the RAS oncogene (a mutation occurring in approximately 30% of human cancers), induces tumour features in an epithelium via coordinated physical changes of all cells forming the affected tissue. Published in the scientific journal Science Advances, the new work suggests that future cancer treatments should target both the biological processes underlying the disease and the evolving mechanical structure of the affected tissue.

New biosensor detects inflammatory marker in muscle with high sensitivity

In a recent publication in the journal Nanophotonics, IBEC researchers present a new biosensor for the direct and sensitive detection of the protein interleukin-6 in muscle, an indicator of inflammation and potential disease, proving the high performance of the device on bioengineered 3D skeletal muscles. This new approach may result in a promising tool for measuring the efficacy of drug candidates for diseases where inflammation is present such as muscular dystrophy.